Late-life depression in individuals with Alzheimer's disease and healthy
 
   Lead Investigator:    Janneke Koerts
   Institution      :    University of Groningen, The Netherlands
   E-Mail           :    janneke.koerts@rug.nl
   Proposal ID      :    973



   Proposal Description:
   With this proposal, we want to investigate whether A?? burden interacts with VRF/VI to increase the risk of developing depressive symptoms. We investigate this in a hierarchical manner by first testing the effects of A?? burden and VRF/VI on depressive symptoms separately and then in a final step to investigate the interaction between A?? and VRF/VI. We investigate this separately for people with AD and for healthy people to establish whether there are disease-specific mechanisms.                                                   Hypotheses:  1) People with clinically meaningful depression will have lower CSF A??-42 levels than people without clinically meaningful depression                        2) People with clinically meaningful depression will show more VRF/VI than people without clinically meaningful depression                                    3) A?? and VRF/VI will interact and thereby additionally increase depressive symptoms